Yes, it is possible to cancel a flight with American Airlines and receive a refund, depending on your ticket type. Refundable tickets are straightforward, allowing you to cancel and receive your money back directly to your payment method. Non-refundable tickets usually provide a travel credit for future use, though there are exceptions, such as significant flight schedule changes or emergencies. To cancel your flight, visit the American Airlines website, log in, and access "My Trips." Select your flight and follow the cancellation process.